Are Excess Polyunsaturated Fats (PUFAs) to blame for the epidemic of Chronic Diseases? With Chris Knobbe, MD

Dr. Knobbe began his practice of ophthalmology in 1994, after completing his residency training at the University of Colorado Health Sciences Center, in Denver, Colorado, USA. He was certified by the American Board of Ophthalmology in 1997 and has remained board-certified since then.

Eye physician and surgeon, Chris A. Knobbe, MD, had been in practice nearly 20 years when, in 2013, he asked himself the question, “Could macular degeneration be a ‘Westernized disease’? Could AMD be a disease that is the result of a Westernized diet?” That question would forever change his life.

The hypothesis that Dr. Knobbe would proffer holds that macular degeneration, which is the leading cause of irreversible vision loss and blindness in developed nations, is not only preventable, but treatable in the early to moderate stages, with an ancestral diet.

Time stamps:

0:11:08 Podcast Begins

0:12:15 Chris Knobbe’s Background

0:19:07 The History of macular degeneration and human diets

0:37:32 Chronic illness and obesity was once virtually nonexistent 

0:48:41 When did PUFAs come onto the scene?

0:55:40 Increase in adipose tissue linoleic acid of US adults in the last half centuryhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642429/

0:57:18 Is olive oil healthy?

0:58:47 PUFA’s are the cause of chronic illness

1:02:29 The best health advice anyone could give

1:09:35 Dietary Stearic Acid Leads to a Reduction of Visceral Adipose Tissue in Athymic Nude Micehttps://www.researchgate.net/publication/265650090_Dietary_Stearic_Acid_Leads_to_a_Reduction_of_Visceral_Adipose_Tissue_in_Athymic_Nude_Mice

1:14:41 Why you need animal fats

1:17:32 Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in micehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180905/

1:18:41 Beef tallow increases apoptosis and decreases aberrant crypt foci formation relative to soybean oil in rat colonhttps://pubmed.ncbi.nlm.nih.gov/15572298/

1:21:56 Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/

1:23:26 Fat and essential fatty acid in mammary carcinogenesishttps://academic.oup.com/ajcn/article-abstract/45/1/218/4694942?redirectedFrom=fulltext

1:29:01 The ‘Displacing Foods of Modern Commerce’ Are the Primary and Proximate Cause of Age-Related Macular Degeneration: A Unifying Singular  Hypothesishttps://www.sciencedirect.com/science/article/abs/pii/S0306987717305017?via%3Dihub

1:31:42 Stop fearing carbs

1:35:43 Eating nutrient-dense foods

1:38:08 Chris Knobbe, the radical heart eater!

1:39:37 Where to find Chris Knobbe

1:41:53 Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabeteshttps://www.karger.com/Article/FullText/446704

1:45:01 Epidemiological studies in a total highland population, Tukisenta, New Guinea: Cardiovascular disease and relevant clinical, electrocardiographic, radiological and biochemical findingshttps://www.sciencedirect.com/science/article/abs/pii/0021968173900313

1:45:28 Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studieshttps://pubmed.ncbi.nlm.nih.gov/7270479/

1:47:44 All about fructose

1:51:29 Impact of Carnivory on human development and evolution revealed by a new unifying model of weaning on mammals https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032452

1:52:57 Efficacy of dietary on chain saturated fatty acid pentadecanoic acid Parallels brought associated health benefits and humans: could it be essential?https://www.nature.com/articles/s41598-020-64960-y

1:54:17 Differentiation of lard, chicken fat, be fat and mutton fat by CGMS and EA-IRMS techniqueshttps://pdfs.semanticscholar.org/6f14/c8a71b879d9fca432bf1b5c238e5376d043b.pdf

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